主讲人：Philippa Marrack教授 美国科学院院士
题 目：B cell heterogeneity
Brief Introduction of Professor Philippa Marrack
Philippa Marrack is a world-renowned immunology researcher whose groundbreaking work on T-cells has impacted the health of people across the world. Her findings shape medicine’s current understanding of the human immune system, vaccines, HIV, and other immune disorders.
For more than four decades together with her husband, John Kappler, she has, and continues to, unraveled the mysteries of the immune system; how it protects us from external threats when it is working and how it can lead to autoimmunity and allergies when it malfunctions. They identified and isolated the T-cell receptor, a primary sentinel for the immune response. They learned how the body makes and selects an effective array of T cells that recognize and attack potentially harmful foreign proteins while leaving the body's own tissues alone. They discovered superantigens, virulent toxins that cause an overwhelming and disastrous immune response that occurs in maladies such as toxic shock syndrome and food poisoning.
Born in England, Marrack earned her doctorate of philosophy degree in biological sciences at Cambridge University. During her career, Marrack has published more than 450 peer-reviewed journal articles. She has been a member of the U.S. National Academy of Sciences since 1989, a fellow of the Royal Society in Great Britain since 1997 and was elected to National Women’s Hall of Fame in 2015. Marrack is also a member of American Academy of Arts and Sciences and the U.S. Institute of Medicine. Together with his husband, she has won numerous prestigious awards including the Louisa Gross Horwitz Prize and Wolf Prize in Medicine.